Table 4.

Mediation analyses of the effect of cranial radiation (per 10Gy) on functional outcomes mediated by growth hormone deficiency (yes/no).

Outcome	Direct Effect of Cranial Radiation (95% CI)	Direct Effect P-value	Indirect Effect of Growth Hormone Deficiency (95% CI)	Indirect Effect P-value	Total Effect (95% CI)	Total Effect P-value
Vocabulary	−0.41 (−0.61, −0.20)	<0.001	−0.01 (−0.04, 0.02)	0.45	−0.42 (−0.63, −0.21)	<0.001
Visual Speed	−0.57 (−0.75, −0.38)	<0.001	−0.01 (−0.03, 0.01)	0.46	−0.58 (−0.76, −0.39)	<0.001
Flexibility	−0.93 (−1.28, −0.57)	<0.001	−0.03 (−0.07, 0.02)	0.26	−0.95 (−1.31, −0.59)	<0.001
Fluency	−0.38 (−0.58, −0.19)	<0.001	−0.03 (−0.05, −0.00)	0.048	−0.41 (−0.62, −0.20)	<0.001
Task Efficiency	0.37 (0.08, 0.65)	0.011	0.02 (−0.01, 0.06)	0.21	0.39 (0.10, 0.68)	0.008
Emotional Regulation	0.12 (−0.10, 0.34)	0.28	0.02 (−0.00, 0.05)	0.100	0.14 (−0.09, 0.38)	0.22
Physical Function	−0.50 (−0.68, −0.31)	<0.001	−0.02 (−0.04, 0.00)	0.097	−0.52 (−0.71, −0.32)	<0.001
Bodily Pain	−0.22 (−0.41, −0.03)	0.025	−0.02 (−0.05, 0.00)	0.053	−0.24 (−0.45, −0.04)	0.020
General Health	−0.17 (−0.39, 0.04)	0.12	−0.04 (−0.07, −0.01)	0.011	−0.21 (−0.45, 0.03)	0.092
Vitality	−0.15 (−0.34, 0.05)	0.15	−0.03 (−0.06, −0.01)	0.011	−0.18 (−0.40, 0.04)	0.11
Social Function	−0.27 (−0.47, −0.08)	0.005	−0.02 (−0.05, 0.00)	0.063	−0.30 (−0.50, −0.09)	0.004
Mental Health	−0.07 (−0.28, 0.14)	0.52	−0.03 (−0.06, −0.01)	0.014	−0.10 (−0.34, 0.13)	0.39

Note: Effects and 95% confidence intervals (CI) presented in age-adjusted z-scores (μ = 0, σ = 1.0), lower z-scores reflect worse performance or more symptoms.