Table 3.
Eff-Tox Scenarios. True outcome probabilities (πE, πT)TR, desirabilities ϕ{(πE, πT)TR}, and operating characteristics for the usual (non-adaptively randomized) EffTox phase I-II trial design.
| Scenario | Value | 1 | 2 | 3 | 4 | 5 |
|---|---|---|---|---|---|---|
| 1 | (πE, πT)TR | (.20, .10) | (.40,.15) | (.60, .25) | (.65, .35) | (.70, .50) |
| ϕ{(πE, πT)TR} | −.37 | −.13 | .05 | −.01 | −.13 | |
| % Selected | 3 | 26 | 29 | 27 | 13 | |
| # Treated | 6.4 | 16.0 | 16.1 | 12.1 | 9.0 | |
| 2 | (πE, πT)TR | (.2, .05) | (.25, .08) | (.35, .10) | (.40, .15) | (.55, .20) |
| ϕ{(πE, πT)TR} | −.30 | −.26 | −.14 | −.13 | .04 | |
| % Selected | 5 | 11 | 18 | 16 | 49 | |
| # Treated | 8.4 | 9.1 | 10.1 | 9.8 | 22.4 | |
| 3 | (πE, πT)TR | (.40, .10) | (.50, .15) | (.60, .35) | (.65, .60) | (.70, .70) |
| ϕ{(πE, πT)TR} | −.06 | .03 | −.09 | −.35 | −.40 | |
| % Selected | 26 | 51 | 20 | 2 | 0 | |
| # Treated | 16.7 | 27.3 | 11.6 | 3.3 | 0.8 |