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HLA-B*18–restricted CD8+ T-cell responses specific for L-HDAg46–54 drive viral escape and population-level evolution of HDV. (A–E) Details as per the corresponding panels in Figure 1. In this case, the ancestral peptide is denoted as the prototype, and the variant peptide is denoted as the consensus, reflecting a negative association between HLA-B*18 and the viral polymorphism D47E. Representative data from patient 3 are shown in (D) and (E). M, mol/L; PMA, phorbol myristate acetate.
