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. 2019 May;156(6):1820–1833. doi: 10.1053/j.gastro.2019.02.003

Figure 5.

Figure 5

Viral escape in the HLA-B*15–restricted epitope L-HDAg170–179 after superinfection with HDV. (A) Clinical course of HDV/HBV superinfection in patient 18 (HLA-A*24:02+, -B*15:01+, -B*35:02+). (B) Viral sequences in patient 18 at early (week 0 and week 2) and late time points (week 71 and week 200) after superinfection with HDV. All longitudinal sequence variants are shown (n = 4). Dots indicate agreement with consensus across the study cohort. Residues with de novo mutations are shown in red, and residues that revert to wild type are shown in green. The de novo mutation S170N is located in the confirmed HLA-B*15–restricted epitope L-HDAg170–179 and corresponds to the linked footprint (Table 1). Also, the F27L reversion colocalizes with an anchor residue for the pre-described HLA-A*02–restricted epitope L-HDAg26–34. ALT, alanine aminotransferase; T, time.