Fig. 3. Effect of corticosterone injections in the lipid composition of dorsal and ventral hippocampus.

a, b LC-MS analysis of dorsal and ventral hippocampus macrodissected from adult rats submitted to a 4-week protocol of daily injections of corticoterone (CORT) compared with age-matched control injected with vehicle (VEH). For lipid nomenclature, see Methods section. Bar graphs indicate fold-change of average relative mol% of all lipids measured, normalized to VEH (mean ± SEM, N = 9 for dorsal hippocampus of VEH; N = 10 for remaining groups). Upper panels, heatmap indicates individual plot of normalized average mol% of each lipid class in CORT-treated animals. Values represented in gradient color, blue indicates below 1 and red indicates above onefold-change, respectively, normalized to VEH. Descriptive statistics listed in Supplementary Tables 4 and 5. *p < 0.05, **p < 0.01, and ***p < 0.001 in two-tailed Student’s t test