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. 2019 Apr 26;9:143. doi: 10.1038/s41398-019-0477-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Representative microphoto of doublecortin (DCX) and postsynaptic density-95 (PSD95) staining in the DG of adult mouse showing the granular cell layer (GCL) as well as inner and medial/outer molecular layers (IML and M/OML, respectively) of DG. b Chronic stress decreases the density of DCX+ cells (immature neurons) whose dendritic tree reaches the IML (named as short DCX+ cells), whereas it does not affect the DCX+ cells whose dendritic tree reaches the M/OML (namely, long DCX+ cells). c Illustration of three-dimensional (3D) reconstruction of short DCX+ cells under control (CON) and stress (STR) conditions. d, e Short DCX+ immature neurons exhibited higher dendritic volume in stressed animals in comparison to controls without significant alteration of their total dendritic length. f Sholl analysis of short DCX+ cells revealed no differences of intersections number between control and stressed DCX+ immature neurons. g Representation of 3D reconstruction of long DCX+ cells in the DG of control and stressed animals. h, i In contrast to short DCX+ cells, the dendritic volume and total dendritic length of long DCX+ immature neurons is lower in stressed animals when compared to controls. j Sholl analysis of long DCX+ cells showed reduced number of intersections at the distal part of long DCX+ cells of stressed animals. All numerical data are shown as mean ± S.E.M. (*p < 0.05)