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. 2019 Apr 26;10:1943. doi: 10.1038/s41467-019-09914-3

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2019 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — IgG and IgM repertoires across Zika virus (ZIKV) proteome following Zika virus infection. a Number of bound phage clones isolated using ZIKV GFPDL affinity selection against flavivirus naive negative control serum, pooled serum samples from five acutely ZIKV-infected patients on day 0 and day 7 of hospital visit, and urine sample on day 7 of hospital visit (day 0 of hospital visit corresponds to 0–3 days since onset of symptoms for these five patients). b, c Schematic alignment of the peptide sequences recognized by IgM (b) and IgG (c) antibodies in ZIKV-infected human sera (day 0 and day 7) and urine (day 7) and flavivirus naive negative control serum, identified by panning with ZIKV-GFPDL. The amino-acid designation is based on the ZIKV polyprotein sequence encoded by the complete ZIKV-ICD genome (Supplementary Fig. 1). Bars indicate identified epitopes in the different structural (C, prM, E) and non-structural (NS) genes on the ZIKV polyprotein sequence. Graphical distribution of representative clones with a frequency of >2, obtained after affinity selection, are shown. The horizontal position and the length of the bars indicate the peptide sequence displayed on the selected phage clone to its homologous sequence in the ZIKV sequence on alignment. The thickness of each bar represents the frequency of repetitively isolated phages. Phage sequences and clonal frequency is shown in Supplementary Table 3