Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Apr 26;10:1943. doi: 10.1038/s41467-019-09914-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2019 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — Structural representation of antigenic sites identified in ZIKV-E protein. a (Left panel) Heat map showing sequence conservation on one monomer chain of mature ZIKV-E protein structure (PDB# 5JHM) based on comparison with several Zika virus (ZIKV) isolates (Paraiba, Uganda-1947, Nigeria-1968, Senegal-2001, Micronesia-2007, and Brazil-2016 strains) and (right panel) ZIKV vs. other flaviviruses (Dengue virus (DENV) 1 to 4, West Nile virus, Yellow Fever virus and ZIKV). The heat map has been color coded from red (0) to green (1), where green denotes complete conservation. b Antigenic sites within ZIKV-prM/E identified by the GFPDL analysis are depicted in blue on the structures of both immature (PDB 5U4W) and mature ZIKV-E (PDB 5JHM). Domain I is shaded in light gray (PDB 5JHM), pr domain is shaded in yellow and M in pink (PDB 5U4W). PDB Structure# 5U4W encompasses residues 288–794 and PDB structure# 5JHM encompasses residues 313–699 based on ZIKV_ICD polyprotein sequence (Supplementary Fig. 1)