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. 2019 Apr 26;10:1943. doi: 10.1038/s41467-019-09914-3

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2019 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Binding of Zika virus (ZIKV)-infected human serum and urine to NS1, E, and E-dIII in SPR. Serum (a, c, d) and urine (b, d, f) samples collected at different time points from adults post-ZIKV infection (days 0, 3, 7, and 28) were analyzed for total binding to purified NS1 (a, b), ZIKV-E (c, d), and ZIKV-E-domain III (e, f) proteins. Total antibody binding is represented in SPR resonance units. Maximum resonance unit (Max RU) values for protein binding by serum or urine antibodies obtained from each individual at different time point post-ZIKV exposure are linked by connecting lines. Source data are provided as a Source Data file