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. 2019 Apr 26;10:1943. doi: 10.1038/s41467-019-09914-3

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2019 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Relationship between serum antibody affinity with Zika virus (ZIKV) clinical symptoms. Antibody off-rate constants of the polyclonal serum sample interaction with recombinant ZIKV-E (a) and NS1 (b) proteins on day 7 visit as measured by SPR was correlated with total number of symptoms on day 28 visit for the corresponding patient. Inverse Spearman correlations were observed between anti-ZIKV-E antibody affinity on day 7 measured by SPR vs. number of symptoms on day 28 (r = 0.592; p = 0.01569). Source data are provided as a Source Data file