Fig. 8.

CSF-1 modulates CSF-1R recruitment on chromatin within a few hours. a Repartition of CSF-1R ChIP-seq peaks and the intersection of CSF-1R and H3K4me3 peaks on the genome of monocytes exposed for 6 h to 100 ng/mL CSF-1. Reference genome is shown on Fig. 3b. b Heatmap centered on CSF-1R peaks (top) and on gene transcription starting sites (TSS) of CSF-1R and H3K4me3 peaks in unstimulated monocytes (0 h) and monocytes exposed to CSF-1 for 6 h (6 h). c ChIP-Seq experiments showing CSF-1R, H3K4me1 and H3K4me3 peak localization on PU.1, CSF2RB, SYK and STAT6 genes in monocytes, either untreated (0 h) or treated with CSF1 for 6 h (6 h) or 3 days (72 h) (TSS: transcription starting site, TTS: transcription termination site). d Motif analysis of the CSF-1R ChIP-seq peaks from monocytes stimulated with 100 ng/mL CSF-1 for 6 h