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. 2019 Mar 1;47(8):4272–4291. doi: 10.1093/nar/gkz144

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — LARP4A NTD contains structured and disordered regions. (A) Superimposition of the ¹H-¹⁵N HSQC spectra of the La module (red) and the NTD (black). (B) Comparison of ¹H-¹⁵N HSQC and a subspectrum of {¹H}-¹⁵N heteronuclear NOE experiment (saturated - 0.80 control) for La module (top and bottom left panels) and NTD (top and bottom right panels). The signals left in the subtraction spectra on the bottom undergo motions on the pico- to nanosecond timescale. The majority of the NTR resonances are experiencing fast motion. (C) Far-UV CD analysis. Far-UV CD spectra of: left, LARP4A NTD, NTR and La module; centre, 24–287, 79–287, 1–50 and 1–79 mutants compared to the La module; right, L15AW22A, W22F, W22A and L15A mutants compared to 24–287 and La module. Each CD trace is colour labelled. The CD profiles indicate that the N-terminal region contains disordered regions and secondary structure elements (see text).