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. 2019 Mar 1;47(8):3937–3956. doi: 10.1093/nar/gkz128

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Primary cells from prostate tumours differentiate in response to ML-60218. (A) Relative changes in normalized expression of the indicated transcripts, as determined by RT-qPCR, when tumour cells from patients H646, H643, H627 and H637 were treated for 48 h with or without 20 μM ML-60218. Means are indicated by horizontal lines and values for each patient are indicated by symbols. (B) Normalized relative levels of POLR3A, POLR3G and POLR3GL mRNAs in normal and cancer cells from patients H646, H643, H627 and H637, as determined by RT-qPCR. * indicates P < 0.05 relative to normal by t-test. Error bars represent S.E.M. (C) Relative changes in expression of the indicated transcripts, as determined by RT-qPCR, when cells from non-cancerous tumour-adjacent cells from patients H646, H643, H627 and H637 were treated for 48 h with or without 20 μM ML-60218. Means are indicated by horizontal lines and values for each patient are indicated by symbols.