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. 2019 Feb 22;47(8):e46. doi: 10.1093/nar/gkz107

Table 2.

List of known and proposed DMRs associated with imprinted genes

DMR name Known co-ordinates Present co-ordinates Hypermethylated Nearest gene Nanopore RRBS RNA-seq Note
GPR1-ZDBF2 1:63,257,407-63,264,876 p Zdbf2,Gpr1 several transient DMRs (17)
GPR1-PLATR12/LIZ 1:63,200,250-63,200,470 m Zdbf2,Gpr1 229 Gpr1 ICR (17)
SFMBT2 2:10,371,327-10,371,731 m Sfmbt2,Gm13261 75 Sfmbt2 TSS secondary DMR
MCTS2 2:152,686,755: 152,687,275 2:152,686,261-152,687,856 m Mcts2 13 wider than annotation
NNAT 2:157,560,050-157,561,662 2:157,559,825-157,561,802 m Nnat 29 wider than annotation
NESP 2:174,284,269-174,286,690 2:174,283,034-174,287,439 p Nespas 1
NESPAS 2:174,295,707-174,300,901 2:174,294,696-174,300,693 m Gnas 6
GNAS-EXON1A 2:174,326,930-174,329,007 m Gnas
JADE1 3:41,555,359-41,556,940 m Jade1 19 Jade1 TSS secondary DMR
PEG10 6:4,747,209-4,747,507 6:4,746,012-4,749,480 m Peg10 2 wider than annotation
MEST 6:30,736,488-30,737,237 6:30,735,330-30,739,552 m Mest 4
NAP1L5 6:58,906,696-58,907,062 6:58,906,821-58,907,095 m Nap1l5,Herc3 89
NDN 7:62,348,214-62,348,695 m Ndn low coverage
ZIM2 7:6,727,576-6,732,116 7:6,727,344-6,731,296 m Peg3 5
SNURF/SNRPN 7:60,004,992-60,005,415 7:60,003,140-60,005,295 m Snrpn,Snurf 16;343 wider than annotation
INPP5F_V2 7:128,688,274-128,688,642 m Inpp5f lack of coverage in B6Cast, clear DMR in CastB6
H19/IGF2 7:142,580,263-142,582,140 7:142,575,503-142,582,086 p H19 17;35;54,534 wider than annotation
IGF2-DMR0 7:142,669,246-142,670,067 m Igf2,Igf2os,Gm49394 39 known placenta-specific secondary DMR (57)
ASCL2 7:142,968,946-142,969,300 p Ascl2 62 Ascl2 TSS secondary DMR
CD81 7:143,052,956-143,053,090 p Cd81,R74862 463;887 Cd81/R74862 TSS secondary DMR
TSSC4 7:143,068,896-143,069,197 p Tssc4,Trpm5,Cd81 153 Tssc4 TSS secondary DMR
KCNQ1OT1 7:143,295,155-143,295,622 7:143,294,879-143,296,757 m Kcnq1ot1 11 wider than annotation
KCNQ1-INTERGENIC1 7:143,438,058-143,438,341 p 205 secondary DMR with unannotated imprinted expression
KCNQ1-INTERGENIC2 7:143,445,526-143,445,944 p Gm27901 67 secondary DMR with unannotated imprinted expression
CDKN1C 7:143,459,775-143,459,891 p Cdkn1c,Gm4732 355 Cdkn1c secondary DMR
GAB1 8:80,859,569-80,859,745 m Gab1 221 known Gab1 placental TSS secondary DMR (58)
RASGRF1 9:89,879,568-89,879,853 9:89,879,601-89,880,045 p Rasgrf 69
ZAC1 10:13,090,470-13,091,527 10:13,090,313-13,092,161 m Plagl1 12 wider than annotation
U2AF1-RS1 11:22,971,842-22,972,319 11:22,971,545-22,973,999 m Zrsr1 3 wider than annotation
GRB10 11:12,025,482-12,026,332 m Grb10 lack of coverage in B6Cast, clear DMR in CastB6
GTL2/DLK1 12:109,526,740-109,528,734 12:109,527,519-109,528,845 p Gm27528,Gm27528 52 narrower than annotation
MEG3 12:109,540,792-109,541,676 p Meg3,Mir1906-1,Gm27300,Gm27596 207;776 known Meg3 TSS secondary DMR (59)
MEG3-INTRON 12:109,556,071-109,556,162 m Meg3 921 Meg3 intronic secondary DMR
RIAN 12:109,612,8804-109,612,962 m Rian,Mir1188, Mir341 304 Rian intronic secondary DMR
PEG13 15:72,806,335-72,811,649 15:72,809,183-72,811,180 m Peg13 14 narrower than annotation
SLC38A4 15:97,053,880-97,056,427 m Slc38a4 9 known TSS secondary DMR (60)
AC158554.1 15:97,166,956-97,167,257 m AC158554.1 403;406 lincRNA TSS secondary DMR
PDE10A 17:8,772,760-8,773,118 m Pde10a 474;701 Pde10a intronic secondary DMR
PARK2 17:11,123,807-11,124,219 m Park2 222;289;488;597; 782;827;852 seven Park2 intronic secondary DMRs
SLC22A2 17:12,607,783-12,608,088 m Slc22a2 452 Scl22a2 intronic secondary DMR
IGF2R/AIR 17:12,741,297-12,742,707 17:12,741,160-12,742,949 m Igf2r,Airn 8
IGF2R-TSS 17:12,769,605-12,770,120 p Igf2r,Airn,Gm23833 37 known Igf2r TSS secondary DMR (2)
SMOC2-INTERGENIC 17:14,590,437-14,590,640 m Smoc2, Thbs2 862 secondary DMR with unannotated imprinted expression
IMPACT 18:12,972,197-12,973,741 18:12,972,182-12,974,748 m Impact 7 wider than annotation

A check mark is shown where RRBS and RNA-seq evidence supports the DMR. The DMR rank is shown when supporting nanopore data exists.