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. 2019 Feb 22;47(8):3888–3903. doi: 10.1093/nar/gkz119

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — SET2-H366N rescues H3K36 methylation genome-wide in spt6-1004. (A–C) Heat maps depicting H3K36me2 levels (relative to H3) (A), H3K36me3 levels (relative to H3) (B) and Set2-HA levels (relative to Rpb1) (C) for all non-overlapping genes that code for protein (n = 3522). All values that had a log fold change of below −2 or above 2 have been set to −2 or 2, respectively. (D-F) H3K36me2 (D), H3K36me3 (E) and Set2-HA (F) levels at genes that show rescue of H3K36 methylation (STE11, RIX1) and genes where rescue of H3K36 methylation is not observed (ADH1, TDH3). All data have been normalized to an S. pombe spike-in control.