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. 2019 Apr 25;28(9):620–631. doi: 10.1089/scd.2018.0213

FIG. 5.

FIG. 5.

Ablation of stat3 abolished the effect of LPS in improving MSC-mediated protection. MSCs with or without stat3 siRNA transfection were infused into the coronary circulation. (A–C) Representative LVP recording traces from hearts infused with vehicle, scramble control siRNA-treated MSCs + LPS, and stat3 siRNA-treated MSCs + LPS as a function of time (n = 5). The LVDP in vehicle (square), stat3 siRNA group (circle), and scramble siRNA group (triangle, n = 5) is presented. The line graphs represent changes in LVDP (% of equilibrium, D), +dP/dt (% of equilibrium, E), −dP/dt (% of equilibrium, F), and EDP (G) over time. Results are reported as the mean ± SEM. *P < 0.05 versus vehicle; #P < 0.05 versus stat3 siRNA + LPS group, as determined by two-way ANOVA followed by Tukey post hoc test. Arrows represent the starting time points of ischemia. siRNA, small interfering RNA.