Table 1.
LPS Induces Differential Gene Expression of Paracrine Factors and Intracellular Signaling Molecules in WT MSCs, But Not in MyD88−/− MSCs
| Gene symbol | Name | log2 fold change | FDR (adjusted P value) | stat3 binding site | Function | ||
|---|---|---|---|---|---|---|---|
| WT | Myd88−/− | WT | Myd88−/− | ||||
| CCL2/MCP1 (NM_011333) | The chemokine (C-C motif ligand 2) | 4.99 | −0.14 | 3.8E-168 | 0.998 | 0 | Angiogenesis apoptosis |
| CCL7 (NM_013654) | The chemokine (C-C motif ligand 7) | 4.04 | 0.15 | 5.74E-146 | 0.998 | 1 | Angiogenesis |
| FGF7 (NM_008008) | Fibroblast growth factor 7 | 2.23 | −0.25 | 4.84E-53 | 0.999 | 0 | Stimulates proliferation of epithelial cells and promote angiogenesis |
| CCL9 (NM_011338) | The chemokine (C-C motif) ligand 2 | 1.02 | −0.35 | 1.01E-09 | 0.999 | 0 | Promote tumor cell survival |
| Cxcl12/SDF-1 (NM_021704) | Cxcl12 chemokine (C-X-C motif) ligand 12 | −0.45 | 0.17 | 0.09 | 0.999 | 1 | |
| Igf1 (NM_001111274) | Insulin-like growth factor 1 | −1.51 | −0.16 | 0.09 | 0.999 | 1 | |
| Igfbp5 (NM_010518) | Insulin-like growth factor binding protein 5 | −1.51 | −0.18 | 5.87E-06 | 0.999 | 0 | Tumor suppressor |
| Hif1a (NM_010431) | Hypoxia-inducible factor 1-alpha, | 0.57 | −0.12 | 0.006 | 0.999 | 1 | |
| NFKBIZ (NM_001159394) | mRNAs of IκBζ | 2 | −0.09 | 9.11E-48 | 0.999 | 1 | |
| Ier3 (NM_133662) | Immediate early response 3 | 1.27 | 0.04 | 4.55E-17 | 0.999 | 1 | This gene functions in the protection of cells from Fas- or TNF type alpha-induced apoptosis |
| Fas (NM_007987) | TNF receptor superfamily member 6 | 1.58 | 0.196 | 2.06E-20 | 0.998 | 0 | Induce apoptosis |
| Pak3 (NM_001195046) | p21 protein (Cdc42/Rac)-activated kinase 3 | 0.62 | 0.12 | 0.0006 | 0.999 | 0 | |
FDR, false discovery rate; LPS, lipopolysaccharides; MSC, mesenchymal stem cell; TNF, tumor necrosis factor; WT, wild type.