miR-302 expression in AEC after SpT4 infection. (A) qRT-PCR analysis of miR-302–367 polycistron (miR-302b/c/a/d family and miR-367) from isolated lung epithelial cells of mouse distal lungs at 0, 2, 7, 14, and 30 dpi. (B) In situ hybridization of digoxigenin-labeled LNA miR-302c antisense probe and LNA-scrambled control probe (Exiqon) on lung tissue sections at 0 and 7 dpi. Arrowheads point to the alveolar epithelial cells. (Scale bars: 50 μm.) Data shown are means ± SEM (A, n = 4 per group). *P < 0.05; **P < 0.01.