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A putative allosteric drug binding pocket is revealed by three holo macrostates. (A) A comparison of the CCR2 crystal structure (white cartoon) with helices V, VI, and VII (red new cartoon) of one holo macrostate. The pocket is shown in red surface. (B) A closer view of the pocket from the other side of the protein, between helices III and V. (C) Small organic probes used for computational fragment mapping are multicolored.
