Fig. 2.

Peptide-specific cytokine detection at baseline and week 12. Cytokine levels were measured by ELISA in the supernatant of PBMC cultures at each time point and stimulated in vitro with the given peptide for 6 d. (A) IL-10 was significantly increased by week 12 in response to MBP2 (P = 0.028), MBP3 (P = 0.18), MBP4 (P = 0.43), PLP (P = 0.18), MOG1 (P = 0.025) and showed a trend for MOG2 (P = 0.69) and AQP4 (P = 0.063) but not for MBP1 (P = 0.465). (B) IFN-γ levels were not significantly different between time points for any of the peptides.