Fig. 6.

Integrated working model depicts the proposed roles for cox1/2 during renal MCC fate choice and differentiation in the zebrafish pronephros. (A) The intermediate mesoderm (gray), which gives rise to the embryonic kidney, includes a populace of bipotential renal progenitors (black circles) that can form MCCs or transporter cells. Expression of cox1/2 supports adoption of MCC fate, and subsequently promotes basal body docking during MCC differentiation. (B) Prostaglandin signaling in renal progenitors is essential for MCC versus transporter fate in the proximal segments and also modulates distal segment fate, where cox1/2 deficiency is associated with altered DE/DL domains.