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. 2019 Apr 4;116(17):8457–8462. doi: 10.1073/pnas.1902119116

Fig. 3.

Fig. 3.

VSMC-EP4 deficiency causes aortic elastin fiber degradation in mice. WT (EP4f/f) and VSMC-EP4−/− mice were infused with AngII (1,000 ng/kg per min) for 28 d. Saline infusion was used as the control. Aortas were collected for the examination of vascular morphology and structure. (A) Representative hematoxylin and eosin staining of the aortas of WT and VSMC-EP4−/− mice receiving saline or AngII treatment. (Scale bars: 100 μm.) (B) Representative EVG staining of aortic elastin in saline- or AngII-treated WT and VSMC-EP4−/− mice. (Scale bars: 100 μm.) (C) Quantification of aortic elastin degradation in B. n = 8–14; *P < 0.05; ***P < 0.001.