Table 1.

Summary of protein biomarkers surveyed for colonic adenomagenesis from mouse to rat to human

		Animal model*			Panels: human (H); conserved (C)
Gene symbol	Protein name	ApcMin/+ vs. +/+	ApcPirc/+ vs. +/+	This report†
APCS	Serum amyloid P-component	1	ND	0
CD44	CD44 antigen	3	0	0
CDH2	Cadherin 2, type 1, N-Cadherin (neuronal)	3	ND	0
CFI	Complement factor I	2	0	0
CRP	C-reactive protein, pentraxin-related	2	ND	E	H
DPP4	Dipeptidyl-peptidase 4	3	ND	0
EGFR	Epidermal growth factor receptor	1	D	0
F5	Coagulation factor V	2	E	E	H, C
FETUB	Fetuin B	1	ND	0
HPX	Hemopexin	2	E	0
ITIH3	Inter-α trypsin inhibitor, heavy chain H3	1	0	0
ITIH4	Inter-α trypsin inhibitor, heavy chain 4	1	E	E	H, C
LRG1	Leucine-rich α-2 glycoprotein	1	E	E	H, C
PI16	Peptidase inhibitor 16	3	ND	D
QSOX1	Quiescin Q6 sulfhydryl oxidase 1	2	ND	E
SOD3	Superoxide dismutase 3, extracellular	3	ND	0
THBS4	Thrombospondin 4	3	ND	0
VITDBP	Vitamin D-binding protein	1	ND	0
VTN	Vitronectin	1	E	E	H, C

^*Apc^Min/+ vs. ^+/+ data from Ivancic et al. (6): 1, high-replicate, high–statistical-confidence proteins were identified as being statistically differentially expressed in at least three out of four samples at the 52- and/or 66-d time points. Statistical significance was defined as having a U value less than 0.05 and a corresponding q value less than 0.05. 2, The category with high replicates but reduced statistical confidence included proteins that had statistically relevant differential expression in only one reciprocally labeled sample, or single peptide identifications where no statistical calculations could be made. 3, The proteins with low-replicate results that had little or no statistical substantiation either displayed no reciprocal sample validation, or the protein had only a single unique peptide hit changing at a log₂ ratio of 1.0 or greater. Apc^Pirc/+ vs. ^+/+ data from Ivancic et al. (7): 0, no significant difference observed; D, diminished in sera from the F₁ Apc^Pirc/+ rat vs. F₁ wild-type rats; E, enhanced in sera from the F₁ Apc^Pirc/+ rat vs. F₁ wild-type rats; ND, not detected.

^†This report: 0, no significant difference observed; D, diminished in polyps; E, enhanced in growing adenomas.