Table 1.

¹H and¹³C NMR data for lepadin I (1) (TFA salt, CDCl₃, 23˚ C)

	1Ha, δ, mult (J, Hz)	13Cb δ (mult)	COSYa	NOESYa	HMBCa
1
2	3.49, m	55.8 (CH)	9, 3	3, 4ax	9
3	5.04, q (2.8)	67.8 (CH)	2, 4ax, 4eq	2,4ax, 4eq, 9	1”, 4, 5, 9
4ax	2.48, d (15.6)	28.9 (CH2)	3, 4eq, 5	3, 4eq, 4a, 1’	2, 3, 8a, 4a, 5
4eq	1.63, mc		3, 4ax	3, 4ax, 4a,	8a, 4a, 5
4a	1.54, md	37.5 (CH)	4eq, 5	4ax, 4eq, 8a, 5, 6ax	3, 8a, 5,
5	1.95, m	34.5 (CH)	4a, 6ax,	4a, 1’, 2’, 6ax	4a, 6, 1’,
6ax	0.81, qd (12.6, 3.3)	31.2 (CH2)	5, 6eq, 7eq, 7ax	4a, 5, 6eq, 7ax, 7eq, 8ax	4a, 5, 7,8
6eq	1.87, brd (12.6)		6ax, 7ax, 7eq	5, 6ax, 1’, 2’	4a, 8,
7eq	1.54, md	19.9 (CH2)	6eq, 7ax,	6ax, 8eq, 7ax	8a, 5
7ax	1.74, qt (13.5, 3.3)		6eq, 6ax, 7eq, 8eq, 8ax	6ax, 8eq, 7eq,	6, 8
8αx	1.64, mc	29.3 (CH2)	8a, 8eq, 7ax	6ax, 8a, 8eq,	8a, 4a, 6, 7
8eq	2.01, d (14.5)		8a, 8ax, 7eq	7ax, 7eq, 8ax	8a, 4a, 6, 7
8a	3.46, m	57.4 (CH)	4a, 8ax, 8eq	4ax, 4a, 8ax, 8eq	7
9	1.31, mh	14.8 (CH3)	2	3, 2”	2, 3
1”		164.6 (Cq)
2”	5.74, d (14.9)	111.7 (CH)	4”	4”	2, 1”, 3”
3”	8.07, d (14.9)	150.0 (CH)	3”	3”	1”, 2”, 5”
4”
5”	2.33, s, 3H	14.2 (CH3)			3”
1’	0.92, mf 1.36, me	33.1 (CH2)	2’	4eq, 5, 6eq	5, 3’, 2’
2’	1.07, m 1.31, me	26.1 (CH2)	1’, 3’	5, 6eq	1’, 3’
3’	1.20, mg	30.3 (CH2)	2’, 4’		1’, 4’, 5’
4’	1.24, mg	30.0 (CH2)	3’		6’, 5’ 3’,
5’	1.26, mg 1.36, me	25.8 (CH2)			7’,
6’	1.39, me	37.7 (CH2)	7’
7’	3.57, m	71.8 (CH)	6’, 8’		5’, 9’
8’	1.39, me	39.9 (CH2)	7’, 9’
9’	1.35, me 1.44, me	19.3 (CH2)	8’, 10’		7’, 8’
10’	0.91, t (6.8)f	14.3 (CH3)	9’		8’, 9’
NH	8.23, bs

^a600 MHz, in the presence of Et₂NH•TFA buffer (~20 mM).

^b, 150 MHz, multiplicities assigned by APT and edited HSQC.

^c-hoverlapped signals. i signal overlapped.