Table 1.
Baseline demographics by homologous recombination deficiency status.
| Characteristic | All (n=250) |
non-HRD (n=152) |
HRD (n=98) |
P-value |
|---|---|---|---|---|
| Age | ||||
| <50 | 56 (22.4) | 23 (15.1) | 33 (33.7) | <0.001 |
| 50-50 | 72 (28.8) | 40 (26.3) | 32 (32.7) | |
| 60-69 | 62 (24.6) | 42 (27.6) | 20 (20.4) | |
| >70 | 60 (24.0) | 47 (30.9) | 13 (13.3) | |
| Disease site | ||||
| Ovary | 216 (86.4) | 131 (86.2) | 85 (86.7) | 0.090 |
| Fallopian tube | 13 (5.2) | 5 (3.3) | 8 (8.2) | |
| Primary peritoneal | 21 (8.4) | 16 (10.5) | 5 (5.1) | |
| FIGO stage | ||||
| I | 18 (7.2) | 11 (7.2) | 7 (7.1) | 0.381 |
| II | 14 (5.6) | 10 (6.6) | 4 (4.1) | |
| III | 187 (74.8) | 115 (75.7) | 72 (73.5) | |
| IV | 29 (11.6) | 16 (10.5) | 13 (13.3) | |
| Missing | 2 (0.8) | 0 (0.0) | 2 (2.0) | |
| Histology | ||||
| Serous | 183 (73.2) | 111 (73.0) | 72 (73.5) | 0.425 |
| Endometrioid | 17 (6.8) | 10 (6.6) | 7 (7.1) | |
| Clear cell | 8 (3.2) | 6 (4.0) | 2 (2.0) | |
| Mixed | 7 (2.8) | 3 (2.0) | 4 (4.1) | |
| Undifferentiated | 23 (9.2) | 12 (7.9) | 11 (11.2) | |
| Other | 12 (4.8) | 10 (6.6) | 2 (2.0) | |
| Grade | ||||
| 1 | 6 (2.4) | 3 (2.0) | 3 (3.1) | 0.232 |
| 2 | 12 (4.8) | 10 (6.6) | 2 (2.0) | |
| 3 | 230 (92.0) | 137 (90.1) | 93 (94.9) | |
| Missing | 2 (0.8) | 2 (1.3) | 0 (0.0) | |
| Optimal cytoreduction | ||||
| Yes | 167 (66.8) | 98 (64.5) | 69 (70.4) | 0.565 |
| No | 81 (32.4) | 53 (34.9) | 28 (28.6) | |
| Missing | 2 (0.8) | 1 (0.7) | 1 (1.0) | |
| Initial CA-125 | ||||
| 0-1000 | 144 (57.6) | 98 (64.5) | 46 (46.9) | 0.004 |
| 1001-2500 | 50 (20.0) | 30 (19.7) | 20 (20.4) | |
| >2500 | 49 (19.6) | 19 (12.5) | 30 (306) | |
| Missing | 7 (2.8) | 5 (3.3) | 2 (2.0) |
Data shown are n (column %). HRD, homologous recombination deficient.