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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: J Mol Cell Cardiol. 2019 Feb 15;129:69–78. doi: 10.1016/j.yjmcc.2019.02.009

Figure 2. Development of cardiac-specific GCN5L1 knockout (cKO) mice.

Figure 2.

(A) Mice with LoxP sites surrounding exon 3 of GCN5L1 were crossed to αMHC-MerCreMer mice to produce tamoxifen-inducible, cardiomyocyte-specific knockouts of GCN5L1 (GCN5L1 cKO). (B, C) MerCreMer expression in GCN5L1FL/FL cardiomyocytes leads to significant reductions in GCN5L1 transcript and protein expression. (D, E) No overt contractile phenotype is observed in the isolated hearts of cardiac-specific inducible knockouts. N= 5-12. **** = P < 0.0001 vs. control.