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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Transl Res. 2019 Jan 7;207:70–82. doi: 10.1016/j.trsl.2019.01.001

Figure 4. Effects of e-cig vaping during early development on offspring growth.

Figure 4.

Following gestational and postnatal vaping, fetal and pup weight and crown-rump length were measured on gestational day (GD) 20 and postnatal day (PND) 10, respectively, one day after the last vaping episode. (A) Mean fetal weight in the Juice + Nicotine group was decreased compared with Pair-Fed Control and Pair-Fed Juice groups (P < 0.0001). (B) Pup weight in the Juice + Nicotine group was decreased compared with both Pair-Fed Control (P = 0.0002) and Pair-Fed Juice groups (P < 0.0001). (C) Fetal crown-rump length in the Juice + Nicotine group was decreased compared to the Pair-Fed Control and Pair-Fed Juice groups (P = 0.0002, P = 0.0129, respectively). (D) Following prenatal + postnatal vaping, crown-rump length in the Juice + Nicotine group was decreased compared with that in the Pair-Fed Control and Pair-Fed Juice groups. (P < 0.0001). (E) Postnatal pup weight in the Juice + Nicotine group was decreased compared with the Pair-Fed Control and the Pair-Fed Juice Groups on PND 4–10. Values are mean + SEM, * indicates statistical significance, P < 0.05.