Table 3:
Markers and mediators of systemic injury |
Released from acinar cells |
Trypsin |
Inflammatory cells and their products |
Neutrophils |
NET |
Inflammasome |
Cytokines |
IL-6 |
IL-1β |
TNF-α |
IL-12 |
IL-18 |
Adipokines |
Resistin |
Visfatin |
Lipid mediators: |
Unsaturated fatty acids |
Platelet activating factor |
DAMPs |
HMGB1 |
sRAGE |
ds-DNA |
Histones/ nucleosomes |
S100 proteins |
ATP |
Extracellular matric (e.g. hyaluronan) |