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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: J Thorac Oncol. 2019 Mar 1;14(5):802–815. doi: 10.1016/j.jtho.2018.12.038

FIGURE 4. Combined inhibition of MEK and EGFR is effective and reducing growth of cells with EGFR mutation.

FIGURE 4.

A. Cells were plated at a density of 7,500 cells/well in 96-well plate and treated with vemurafenib or dabrafenib for 96 h then growth was determined. IC50 values for growth inhibition are shown (Right). B. MSK-LX138cl cells were plated at a density of 7,500 cells/well in 96-well plates and treated with trametinib (0–1μM) and osimertinib (0–1μM) for 96 h. Growth inhibition was then determined and combination index calculated using CompuSyn software. Data represent the mean value of growth inhibition ratio at each concentration of the drugs in two independent experiments. Dot plot indicates the combination index and fraction affected (inhibition ratio) of various drug concentrations.