Table 1:

Eligibility Criteria

Inclusion Criteria	Exclusion Criteria
1) Age ≥21 years	1) Chronic renal dysfunction, including ESRD or eGFR < 45ml//min/1.73m2
2) Presents with shortness of breath at rest or with minimal exertion	2) Shock of any kind. Any requirement for vasopressors or inotropes
3) Clinical diagnosis of AHF and presence of > 15 total bilateral B-lines on initial LUS	3) SBP < 100 or > 175mmHg
4) History of chronic HF and any one of the following:  i. Chest radiograph consistent with AHF  ii. Jugular venous distension  iii. Pulmonary rales on auscultation  iv. Lower extremity edema	4) Need for immediate intubation
	5) Acute Coronary Syndrome (ACS) OR new ST-segment elevation/depression on EKG. (troponin elevation outside of ACS is allowed)
	6) Fever >101.5°F
	7) End stage HF: transplant list, ventricular assist device
	8) Anemia requiring transfusion
	9) Known interstitial lung disease
	10) Suspected acute lung injury or acute respiratory distress syndrome (ARDS)
	11) Pregnant or recently pregnant within the last 6 months

ESRD – end stage renal disease; eGFR – estimated glomerular filtration rate, SBP – systolic blood pressure; HF – heart