Table 3:

Exploratory Endpoints

Total DAOOH through 30 and 90 days post-discharge	Association of B-lines at discharge and 30 and 90 day outcomes
Change in biomarkers from presentation to pre-discharge	Association of baseline, discharge, and change with 30 and 90 day outcomes
Time to reach B-lines <15	B lines < 15 at 24 hours and at discharge
Composite of 30-day all-cause mortality, cardiovascular (CV) re-hospitalizations, and CV emergency department (ED) revisits. CV endpoints are defined according to the 2014 ACC/AHA Key Data Elements and Definitions for Cardiovascular Endpoint Events.32 Also for same endpoint, but through 90 days.	All Cause readmissions, All cause ED revisits
Change in physical exam findings and body weight from presentation to pre-discharge	Description of ED pharmacologic treatment
Description of hospital based AHF treatment	Inter and intra-observer agreement
Trajectory of B-line clearance	Assess B-line clearance by sub-group/HF phenotype

DAOOH - Days alive and out of hospital