Table 4:
Comparisons between subjects without pathology and subjects who had at least one type of pathology
| No pathology (N = 23) | At least one pathology (N = 138) | |
|---|---|---|
| Female, N (%) | 13 (57%) | 73 (53%) |
| Age at clinical exam, yrs | 84 (77, 86) | 87 (83, 90)** |
| Age at MRI, yrs | 82 (77, 87) | 87 (82, 90) |
| Age at death, yrs | 84 (78, 89) | 90 (85, 94)** |
| MRI to death, yrs | 4.0 (1.3, 5.9) | 3.0 (1.4, 5.6) |
| Post-mortem interval, hrs | 14 (8, 20) | 15 (10, 20) |
| Clinical exam to death, yrs | 1.0 (0.5, 1.6) | 1.6 (0.7, 3.5)* |
| Education, yrs | 14 (12, 16) | 14 (12, 16) |
| APOE ε4 carrier, N (%) | 2 (9%) | 35 (25%)* |
| 23 | 3 (13%) | 19 (14%) |
| 24 | 1 (4%) | 2 (1%) |
| 33 | 18 (78%) | 84 (61%) |
| 34 | 1 (4%) | 29 (21%) |
| 44 | 0 (0%) | 4 (3%) |
| Clinical scores | No pathology (N = 23) | At least one pathology (N = 138) |
| Mini-Mental State Exam score / 30 | 29 (27, 29) | 28 (27, 29) |
| WMS Logical Memory Delayed Recall / 50 | 21 (16, 25) | 17 (12, 23) |
| Boston Naming / 60 | 56 (54, 58) | 54 (51, 57) |
| Controlled Oral Word Association Test | 34 (25, 43) | 36 (29, 45) |
| WAIS-Block Design / 51 | 20 (16, 27) | 20 (14, 25) |
| AVLT Delayed Recall / 15 | 8 (4, 11) | 6 (4, 8) |
| Trails A / 180 | 47 (36, 56) | 46 (36, 64) |
| Trails B / 300 | 114 (83, 140) | 126 (95, 170) |
| Total UPDRS / 44 | 1 (0, 1) | 1 (0, 2) |
| BDI-II / 63 | 4 (2, 6) | 6 (2, 9) |
| Gray matter volumes (cm3) | No pathology (N = 12) | At least one pathology (N = 90) |
| TIV (1) | 1.57 (1.46, 1.60) | 1.49 (1.39, 1.60) |
| Amygdala | 2.07 (1.93, 2.11) | 1.96 (1.78, 2.17) |
| Hippocampus | 7.35 (6.70, 7.48) | 6.97 (6.42, 7.52) |
| Entorhinal cortex | 3.03 (2.77, 3.37) | 2.82 (2.44, 3.30) |
| Lateral frontal | 55 (51, 71) | 55 (50, 60) |
| Lateral parietal | 37 (32, 43) | 34 (31, 38) |
| Lateral temporal | 68 (63, 77) | 64 (60, 70) |
| Medial frontal | 29 (26, 33) | 27 (25, 30) |
| Medial parietal | 20 (17, 22) | 18 (17, 21) |
Unless indicated otherwise, data shown are median (IQR).
*
= p<0.05
**
= p<0.01
***
= p<0.001.
APOE= apolipoprotein ; AVLT = auditory verbal learning test; BDI = Becks depression inventory; TIV = total intracranial volume; UPDRS = Unified Parkinson’s disease rating scale (modified version used) ; WAIS = Wechsler Adult Intelligent scale