TABLE 1.
Case No. | Age (yrs), Sex | Presenting Sx | Primary, Recurrence, or Progression | Size (cm) | Tx | Intraop Events | Outcome/Subsequent Tx |
---|---|---|---|---|---|---|---|
1* | 66, F | Dizziness, nausea, diaphoresis | Primary | 1.7 × 2.1 × 2.4 (inf); 1.5 × 1.0 × 1.3 (sup) | TSR | Mild CN VI palsy resolved w/ dexameth; stable residual tumor (100 mos) | |
2* | 50, M | Dizziness | Primary | 1.2 × 1.4 × 1.3 | TSR | Signif intraop venous bleeding | Stable residual tumor (30 mos) |
3* | 63, M | VD | Progression (3 mos postop from craniotomy at OSH) | 2.7 × 2.7 × 1.9 | TSR | Repeat TSR for tumor progression (3 mos postop); craniotomy for tumor progression (42 mos after repeat TSR) | |
4 | 59, F | HA, thyroid & adrenal hypopit, VD | Primary (transferred from an OSH due to intraop bleeding during craniotomy) | TSR | Excessive intraop bleeding | Recurrence 6 yrs after GTR, treated w/ repeat TSR, GKRS; stable (79 mos after initial presentation) | |
5 | 77, M | VD | Primary | 2.4 × 2.8 × 2.2 | TSR | Stable after GTR (12 mos) | |
6 | 56, F | Eyeball heaviness, nausea, dizziness | Progression (8.5 yrs after 2 TSRs, 1 craniotomy, CKRS at OSH) | 3.8 × 4.2 × 4.1 | TSR | Diplopia resolved 1 mo postop; proton beam therapy for residual tumor; stable residual tumor (38 mos after initial op at our institution) |
CKRS = CyberKnife radiosurgery; CN = cranial nerve; dexameth = dexamethasone; GKRS = Gamma Knife radiosurgery; HA = headache; hypopit = hypopituitarism; inf = inferior; OSH = outside hospital; signif = significant; sup = superior; Sx = symptoms; TSR = transsphenoidal resection; Tx = treatment; VD = visual deficit.
These cases were previously reported with limited clinical detail in a study of SCO exome profiles.23