Table 1.
Characteristics and medication details for the subset of patients included in the HLA class 1 SAB data seta
| ACR | Control | p-value | |
|---|---|---|---|
| Number of kidney transplant recipients | 34 | 18 | – |
| Age at time of transplantation (years) | 57.9 ± 11.0 | 51.6 ± 11.6 | 0.04 |
| Body mass index at time of transplantation (kg/m2) | 27.7 ± 5.4 | 24.2 ± 4.2 | 0.01 |
| Gender | |||
| Female | 17 (50.0%) | 7 (38.9%) | nsb |
| Male | 17 (50.0%) | 11 (61.1%) | |
| Type of donor | |||
| Living | 7 (20.6%) | 4 (22.2%) | nsc |
| Deceased | 27 (79.4%) | 14 (77.8%) | |
| Re-transplantation | 3 (8.8%) | 0 (0.0%) | nsc |
| HLA-A Mismatchesd | |||
| 0 | 11 (32.4%) | 9 (50.0%) | nsc |
| 1 | 18 (52.9%) | 8 (44.4%) | |
| 2 | 5 (14.7%) | 1 (5.6%) | |
| HLA-B Mismatchesd | |||
| 0 | 3 (8.8%) | 4 (22.2%) | nsc |
| 1 | 18 (52.9%) | 11 (61.1%) | |
| 2 | 13 (38.2%) | 3 (16.7%) | |
| HLA-DR Mismatches | |||
| 0 | 3 (8.8%) | 7 (38.9%) | 0.03c |
| 1 | 20 (58.8%) | 9 (50.0%) | |
| 2 | 11 (32.4%) | 2 (11.1%) | |
| PRA = 0% | 31 (91.2%) | 16 (88.9%) | nsc |
| Therapeutic Arm | |||
| A | 12 (35.3%) | 6 (33.3%) | nsc |
| B | 10 (29.4%) | 3 (16.7%) | |
| C | 12 (35.3%) | 9 (50.0%) | |
| Cold ischemia time: only deceased donors (min) | 739 ± 295 | 637 ± 302 | ns |
aData are given as mean ± standard deviation for quantitative variables and as number (frequency) for categorical variables. P values for quantitative variables were calculated by Mann-Whitney U test, for categorical variables either chi-squared (b) or Fisher’s exact test (c) were employed. (d) According to Fisher’s exact test, there is also no statistically significant differences between the ACR and Control groups when HLA-A and HLA-B mismatches are combined into one group