Fig. 3.

Histopathological assessment of wound healing by hematoxylin and eosin (H&E) staining. Control groups: L (wounds covered with Linitul) and SF (wounds covered with SF scaffolds). Treated groups: ED (wounds treated with Wj-MSCs injected at the edge), C (wounds covered with SF patches cellularized with Wj-MSCs), and ED+C (wounds with SF patches cellularized with Wj-MSCs over the wound bed combined with Wj-MSCs injected at the edge). Abbreviations: Fb fibrin, “*” inflammatory infiltrate and edema, “>” blood vessels, E epidermis, M muscular layer, D dermis, C collagen, SF silk fibroin scaffold, PD papillary dermis, RD reticular dermis. Scale bar 100 μm