Table 6.
Pharmacokinetic parameters of genistein obtained from 11 subjects receiving a single oral administration of soy milk (SOY Phase) and a short-course oral ciprofloxacin followed by a single oral administration of soy milk (CIPRO/SOY phase).
| Pharmacokinetic parameters | Genistein | |||
|---|---|---|---|---|
| SOY phase | CIPRO/SOY phase | |||
| Mean±SD | Median (IQR) | Mean±SD | Median (IQR) | |
| Cmax (ng/mL) | 826.64±462.97 | 731.95 (521.01) | 434.75±276.24∗ | 306.17 (214.37)∗∗ |
| Tmax (h) | 6.00±1.55 | 6.00 (0.00) | 3.27±2.24∗ | 2.00 (2.00)∗∗ |
| AUC0-t (ng.h/mL) | 9583.48±6482.03 | 8911.53 (7711.23) | 4956.98±4263.76∗ | 3834.93 (4106.07)∗∗ |
| AUC0-∞ (ng.h/mL) | 10540.60±7024.65 | 9284.07 (7789.07) | 5791.53±4567.84∗ | 4366.76 (3976.55)∗∗ |
| t1/2 (h) | 7.40±1.20 | 7.26 (1.57) | 7.54±1.69 | 7.16 (1.69) |
Data represent mean±SD and median (interquartile range, IQR). ∗p <0.05 versus SOY phase using a paired t-test. ∗∗p <0.05 versus SOY phase using Wilcoxon's signed-rank test.