Table 1.
SNPs in CDKAL1 gene and risk of gestational diabetes mellitus#.
| SNPs | Genotypes | Cases | Controls | Additive | Dominant | Recessive | Codominant | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | ||||
| rs4712527 | AA | 245 | 208 | 0.21 (0.05-0.69) | 0.019∗ | 0.59 (0.41-0.84) | 0.003∗ | 0.24 (0.05-0.77) | 0.029 | 0.59 (0.43-0.81) | 0.001∗∗ |
| AG | 73 | 96 | |||||||||
| GG | 3 | 12 | |||||||||
|
| |||||||||||
| rs7748720 | AA | 241 | 193 | 0.15 (0.03-0.47) | 0.003∗ | 0.51 (0.36-0.72) | 0.0002∗∗ | 0.18 (0.04-0.55) | 0.007 | 0.51 (0.37-0.70) | 0.00003∗∗ |
| AG | 75 | 107 | |||||||||
| GG | 3 | 15 | |||||||||
|
| |||||||||||
| rs9295478 | GG | 72 | 93 | 2.08 (1.33-3.27) | 0.001∗ | 1.46 (1.01-2.10) | 0.042 | 1.83 (1.26-2.66) | 0.001∗ | 1.44 (1.15-1.81) | 0.002∗∗ |
| GA | 149 | 160 | |||||||||
| AA | 100 | 63 | |||||||||
|
| |||||||||||
| rs6935599 | AA | 72 | 93 | 2.05 (1.31-3.22) | 0.002∗ | 1.45 (1.01-2.10) | 0.044 | 1.80 (1.24-2.62) | 0.002∗ | 1.43 (1.14-1.79) | 0.002∗∗ |
| AG | 149 | 160 | |||||||||
| GG | 99 | 63 | |||||||||
|
| |||||||||||
| rs7747752 | CC | 76 | 96 | 1.96 (1.25-3.09) | 0.004∗ | 1.45 (1.01-2.08) | 0.042 | 1.69 (1.16-2.48) | 0.006∗ | 1.39 (1.11-1.75) | 0.004∗∗ |
| CG | 153 | 159 | |||||||||
| GG | 92 | 60 | |||||||||
|
| |||||||||||
| rs9350276 | AA | 188 | 155 | 0.46 (0.26-0.81) | 0.008∗ | 0.67 (0.49-0.92) | 0.014 | 0.52 (0.30-0.90) | 0.021 | 0.70 (0.55-0.89) | 0.004∗∗ |
| AG | 110 | 122 | |||||||||
| GG | 23 | 39 | |||||||||
|
| |||||||||||
| rs6938256 | AA | 207 | 165 | 0.39 (0.20-0.74) | 0.005∗ | 0.58 (0.42-0.81) | 0.001∗∗ | 0.46 (0.24-0.87) | 0.019 | 0.63 (0.48-0.81) | 0.0005∗∗ |
| AG | 96 | 118 | |||||||||
| GG | 16 | 30 | |||||||||
∗ and ∗∗ indicate that the associations were statistically significant at the 0.20 and 0.05 levels after adjusting for multiple comparisons using the FDR method. #ORs were adjusted for maternal age, maternal BMI, parity, and family history of diabetes.