Table 2.
IC50 values of different extracts and different fractions of leaves Crinum amabile, against various cancer cell lines, using MTS assay. All extract and fraction were exposed for 48 hours with the highest concentration tested being 200 μg/mL. All results were presented as mean ± SEM, of three individual experiments. Triplicate samples were tested in each individual experiment (n = 9).
| Samples | IC50, (μg/mL) | ||||
|---|---|---|---|---|---|
| Breast | Colon | Leukemia | |||
| MCF-7 | MDA-MB-231 | HCT-116 | HT-29 | REH | |
| PE | > 200 | > 200 | > 200 | > 200 | > 200 |
| CE | 116.66±7.99 | 169.92±6.12 | 158.69±8.48 | 126.39±3.96 | > 200 |
| ME | > 200 | > 200 | > 200 | > 200 | > 200 |
| WE | > 200 | > 200 | > 200 | > 200 | > 200 |
|
| |||||
| F1 Fraction | > 200 | > 200 | 60.21±0.88 | > 200 | >200 |
| F2 Fraction | > 200 | 147.52±2.41 | > 200 | > 200 | 117.64±1.50 |
| F3 Fraction | > 200 | 120.59±1.20 | 38.49±1.17 | > 200 | > 200 |
| F4 Fraction | > 200 | 84.62±3.51 | 71.08±2.96 | > 200 | 89.88±0.58 |
| F5 Fraction | 25.61±3.15 | 27.15±1.21 | 40.14±2.53 | 39.53±1.65 | 52.69±8.10 |
| F6 Fraction | 122.03±5.21 | 159.93±5.81 | > 200 | > 200 | > 200 |
|
| |||||
| 5-FU | 2.18±0.20 | 185.58±6.14 | 2.33±0.07 | - | 3.63±0.10 |