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. 2019 Apr 11;2019:3172647. doi: 10.1155/2019/3172647

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Copyright © 2019 Jing Zhao et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Schematic model depicting a possible mechanism that contributes to CD36-mediated podocyte injury of ORG. In the pathogenesis of ORG, after stimulation of adipocytokine such as leptin, the expression of CD36 increased, which is responsible for the FFA uptake in podocytes. Increased CD36 promotes lipid droplet formation in podocytes and further activates NLRP3 inflammasome; the cells release the mature form of inflammatory cytokines such as IL-1β, which causes the injury of podocytes. FFAs: free fatty acids.