Figure 5.

Effects of inhibiting CD36 by SSO on leptin-induced podocyte injury and lipid accumulation. (a) and (c) Differentiated podocytes were incubated in medium, medium containing 15 ng/mL leptin, or medium containing both 15 ng/mL leptin and 50 μM SSO, respectively. The relative mRNA and protein expression levels of CD36 and ADRP (a) and nephrin, podocin, and desmin (c) of podocytes were measured by real-time quantitative PCR and Western blot assay. (b) Representative Oil Red O staining images of podocytes in different groups as indicated (magnification ×400). Values are represented as mean ± SD (n = 3). ^∗P < 0.05 vs. control group, ^#P < 0.05 vs. leptin + SSO group.