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. 2019 Apr 11;2019:3172647. doi: 10.1155/2019/3172647

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Copyright © 2019 Jing Zhao et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of inhibiting NLRP3 by MCC950 on leptin-induced podocyte injury and IL-1β secretion. (a) and (b) Differentiated podocytes were incubated in medium, medium containing 15 ng/mL leptin, or medium containing both 15 ng/mL leptin and 1 μM MCC950, respectively. The relative mRNA and protein expression levels of nephrin, podocin, and desmin (a) and IL-1β (b) of podocytes were measured by real-time quantitative PCR and Western blot assay. Values are represented as mean ± SD (n = 3). ^∗P < 0.05 vs. control group, ^#P < 0.05 vs. leptin + MCC950 group.