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. 2019 Apr 11;2019:3172647. doi: 10.1155/2019/3172647

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Copyright © 2019 Jing Zhao et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of inhibiting NLRP3 by MCC950 on leptin-induced lipid uptake and accumulation of podocyte. (a) and (b) Differentiated podocytes were incubated in medium, medium containing 15 ng/mL leptin, or medium containing both 15 ng/mL leptin and 1 μM MCC950, respectively. (a) The relative mRNA and protein expression levels of ADRP and CD36 of podocytes were measured by real-time quantitative PCR and Western blot assay. (b) Representative Oil Red O staining images of podocytes in different groups as indicated (magnification ×400). Values are represented as mean ± SD (n = 3). ^∗P < 0.05 vs. control group, ^#P < 0.05 vs. leptin + MCC950 group.