Table 1.
Percentage suppression and mean survival time of Plasmodium berghei infected mice after treatment with leaf latex and TLC isolates obtained from A. megalacantha.
| Test substance | Dose (mg/kg/day) | %Parasitemia ± SEM | %Suppression | MST (days) |
|---|---|---|---|---|
| NC | 10 ml/kg | 47.0 ± 3.49 | 0.00 | 6.4 ± 0.25 |
| Latex | 100 | 32.7 ± 1.21∗∗ | 30.4 | 7.2 ± 0.37 |
| 200 | 26.6 ± 2.99∗∗ | 43.4 | 9.0 ± 0.51∗ | |
| 400 | 20.5 ± 1.22∗∗ | 56.4 | 10.1 ± 0.51∗∗ | |
| AM1 | 100 | 31.8 ± 5.05∗∗ | 32.3 | 7.6 ± 0.6 |
| 200 | 22.9 ± 3.73∗∗ | 51.3 | 8.8 ± 0.58∗ | |
| 400 | 15.3 ± 3.78∗∗ | 67.4 | 10.0 ± 0.84∗∗ | |
| AM2 | 100 | 28.3 ± 5.90∗∗ | 39.8 | 7.8 ± 0.49 |
| 200 | 23.2 ± 3.90∗∗ | 50.6 | 8.8 ± 0.37∗ | |
| 400 | 16.8 ± 4.19∗∗ | 64.2 | 9.6 ± 0.68∗∗ | |
| AM3 | 100 | 22.3 ± 4.77∗∗ | 52.6 | 8.2 ± 0.58∗ |
| 200 | 14.4 ± 2.38∗∗ | 69.4 | 9.6 ± 0.55∗∗ | |
| 400 | 9.6 ± 1.75∗∗ | 79.6 | 10.4 ± 0.51∗∗ | |
| CQ | 25 | 0.00∗∗ | 100 | ND |
Values are presented M ± SEM; n =5; ∗ mean value is significant (P<0.05) and ∗∗ mean value highly significant (P<0.001) when compared with negative control (NC) group; ND = no death within the follow-up period; MST= mean survival time in days.