Table 3.
Mean difference of rectal temperature of P. berghei infected mice after treatment with leaf latex and TLC isolates obtained from A. megalacantha.
| Test substance | Dose (mg/kg/day) | T0 D0 (°C) | T0 D4 (°C) | Mean difference |
|---|---|---|---|---|
| NC | 10 ml/kg | 37.8 ± 0.31 | 34.6 ±0.33 | -3.2 (8.5) |
| Latex | 100 | 38.02 ± 0.22 | 35.66 ± 0.13∗ | -2.36 (6.6) |
| 200 | 37.45 ± 0.26 | 35.82 ± 0.31∗ | -1.63 (4.6) | |
| 400 | 37.5 ± 0.28 | 36.16 ± 0.21∗ | -1.34 (3.7) | |
| AM1 | 100 | 37.7 ± 0.19 | 35.9 ± 0.29∗ | -1.7 (4.5) |
| 200 | 37.6 ± 0.37 | 36.6 ± 0.22∗ | -1.0 (2.7) | |
| 400 | 37.7 ± 0.33 | 36.8 ± 0.27∗ | -0.9 (2.4) | |
| AM2 | 100 | 37.6 ± 0.30 | 36.1 ± 0.50∗ | -1.5 (4.0) |
| 200 | 37.4 ± 0.28 | 36.6 ± 0.52∗ | -0.8 (2.1) | |
| 400 | 37.4 ± 0.26 | 36.7 ± 0.31∗ | -0.7 (1.9) | |
| AM3 | 100 | 37.6 ± 0.24 | 36.5 ± 0.17∗ | -1.1 (2.9) |
| 200 | 37.6 ± 0.23 | 36.7 ± 0.17∗ | -0.9 (2.4) | |
| 400 | 37.8 ± 0.33 | 36.9 ± 0.26∗ | -0.9 (2.4) | |
| CQ | 25 | 37.4 ± 0.32 | 37.7 ± 0.26∗ | 0.3 (0.8) |
Values are presented as M ± SEM; n =5; ∗ mean value is significant (P<0.001) when compared with negative control group; T0 D0: temperature before treatment on day zero; T0 D4: temperature after treatment on fifth day (day 4); values in parenthesis indicate % of change.