Table 2.
Decreased lncRNAs related to cellular functions of trophoblast cells in PE.
| LncRNA name | Functions related to PE | Regulating gene/signal pathway | Reference |
|---|---|---|---|
| MALAT-1 | Increases proliferation, decreases apoptosis | unknown | [50] |
| ATB | Increases migration, proliferation, tube-formation of HTR-8/SVneo cells |
unknown | [51] |
| SNHG5 | Promotes cell proliferation, invasion and migration | miR‐26a‐5p/N‐cadherin axis | [52] |
| MEG3 | Reduces apoptosis and promotes migration | unknown | [53] |
| TUG1 | Increases proliferation, migration, and invasion and reduces apoptosis | Ezh2, RND3 | [54] |
| RP11-465L10.10 | Increases cell migration and motility | MMP9 | [30] |
| HOXA11-AS | Increases cell proliferation and migration | Ezh2, Lsd1, RND3 miR-15b-5p/HOXA7 axis |
[55] |
| H19 | Increases cell proliferation | miR-675/NOMO1 Nodal signaling | [56] |
| EGFR-AS1 | Increases cell proliferation | JAK/STAT signaling pathway | [57] |
| linc00473 | Increases cell proliferation and reduces cell apoptosis | TFPI2, LSD1 | [58] |
| PVT1 |
Increases cell proliferation and reduces cell apoptosis | ANGPTL4, EZH2 |
[59] |
| MVIH | Promotes cell growth, migration, invasion and angiogenesis | Jun-B | [60] |
SNHG5, small nucleolar RNA host gene 5; MEG3, maternally expressed gene 3; NOMO1, Nodal Modulator 1; EGFR-AS1, EGFR Antisense RNA1; TFPI2, tissue factor pathway inhibitor 2; LSD1, lysine-specific demethylase 1; ANGPTL4, angiopoietin-like 4.