Table 1. Clinical characteristics of control rats and STZ-induced diabetic rats untreated or treated with PTHrP at 3 months.
| Control | STZ | STZ+P40 | STZ+P80 | STZ+P160 | |
|---|---|---|---|---|---|
| N | 9 | 8 | 8 | 8 | 8 |
| Glucose (mmol/l) | 3.99 ± 0.69 | 29.13 ± 1.08* | 28.96 ± 1.64* | 29.06 ± 1.35* | 30.26 ± 1.75* |
| Systolic blood pressure (mmHg) | 113.0 ± 1.6 | 117.0 ± 1.0 | 110.0 ± 0.8 | 119.0 ± 2.0 | 116.0 ± 2.1 |
| Kidney/body weight (mg/g) | 3.1 ± 0.10 | 5.4 ± 0.06* | 5.8 ± 0.31*# | 6.0 ± 0.17*# | 6.4 ± 0.37*# |
| Ccr (ml/min) | 4.5 ± 0.22 | 5.2 ± 0.38 | 5.3 ± 0.51 | 5.3 ± 0.49 | 5.1 ± 0.33 |
| Albuminuria (mg/24 h) | 11.66 ± 0.81 | 89.49 ± 4.78* | 90.36 ± 3.00* | 90.23 ± 5.73* | 92.35 ± 5.13* |
| Serum calcium (mmol/l) | 2.20 ± 0.05 | 2.13 ± 0.09 | 2.10 ± 0.19 | 2.25 ± 0.10 | 2.14 ± 0.18 |
| Serum phosphate (mmol/l) | 2.12 ± 0.16 | 1.94 ± 0.10 | 2.13 ± 0.27 | 2.03 ± 0.24 | 2.10 ± 0.45 |
Data are means ± S.E. *P<0.05 vs control. #P<0.05 vs STZ group.