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. 2019 Apr 28;25(16):1950–1963. doi: 10.3748/wjg.v25.i16.1950

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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Global-T cell cytokine production in different clinical phases. Peripheral blood mononuclear cells were stimulated by phorbol myristate acetate and ionomycin. A: Representative dot plots depicting the expression of IFN-γ, IL-2 and TNF-α in global CD3+ T cells; B: Cumulative data showing the frequency of global CD3+ T cells expressing IFN-γ, IL-2 and TNF-α in healthy donors and patients in different clinical phases. IFN-γ: Interferon-gamma; TNF-α: Tumor necrosis factor-alpha; HD: Healthy donors; IT: Immune tolerant; IA: Immune active; IC: Inactive carrier; ENEG: Hepatitis B envelope antigen-negative hepatitis. All data are presented as mean ± SD, ^aP < 0.05, ^bP < 0.01, ^cP < 0.001.