Comparison 1. Oxytocin versus no uterotonics or placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Blood loss 500 mL or more after delivery	6	4162	Risk Ratio (M‐H, Random, 95% CI)	0.51 [0.37, 0.72]
2 Need for additional uterotonics	4	3135	Risk Ratio (M‐H, Random, 95% CI)	0.54 [0.36, 0.80]
3 Blood loss 1000 mL or more after delivery	5	4123	Risk Ratio (M‐H, Fixed, 95% CI)	0.59 [0.42, 0.83]
4 Blood transfusion	3	3081	Risk Ratio (M‐H, Fixed, 95% CI)	0.88 [0.44, 1.78]
5 Third stage greater than 30 minutes	1	1947	Risk Ratio (M‐H, Fixed, 95% CI)	2.55 [0.88, 7.44]
6 Mean blood loss (mL)	5	1359	Mean Difference (IV, Random, 95% CI)	‐99.13 [‐181.40, ‐16.85]
7 Maternal haemoglobin concentration (Hb) < 7 g/dL 24‐48 hours PP	2	1073	Risk Ratio (M‐H, Fixed, 95% CI)	0.64 [0.18, 2.26]
8 Mean length of third stage (minutes)	3	294	Mean Difference (IV, Random, 95% CI)	‐3.61 [‐9.06, 1.83]
9 Manual removal of the placenta	6	4281	Risk Ratio (M‐H, Fixed, 95% CI)	1.27 [0.89, 1.82]