Comparison 2. Oxytocin versus no uterotonics or placebo‐subgroup analyses.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Blood loss 500 mL or more after delivery; active v. expectant management	5	4154	Risk Ratio (M‐H, Random, 95% CI)	0.52 [0.37, 0.73]
1.1 Active management	2	2920	Risk Ratio (M‐H, Random, 95% CI)	0.39 [0.22, 0.72]
1.2 Expectant management	3	1234	Risk Ratio (M‐H, Random, 95% CI)	0.62 [0.48, 0.81]
2 Blood loss 500 mL or more after delivery; IM v. IV oxytocin	6	4162	Risk Ratio (M‐H, Random, 95% CI)	0.52 [0.37, 0.73]
2.1 IV oxytocin	3	1978	Risk Ratio (M‐H, Random, 95% CI)	0.41 [0.21, 0.79]
2.2 IM oxytocin	3	2184	Risk Ratio (M‐H, Random, 95% CI)	0.63 [0.46, 0.87]
3 Blood loss 500 mL or more after delivery; oxytocin dose < 10 IU v. 10 IU	5	4154	Risk Ratio (M‐H, Random, 95% CI)	0.52 [0.37, 0.73]
3.1 Oxytocin dose < 10 IU	3	1204	Risk Ratio (M‐H, Random, 95% CI)	0.52 [0.24, 1.14]
3.2 Oxytocin dose 10 IU	2	2950	Risk Ratio (M‐H, Random, 95% CI)	0.56 [0.47, 0.66]
4 Need for additional uterotonics; active v. expectant management	4	3135	Risk Ratio (M‐H, Random, 95% CI)	0.54 [0.36, 0.80]
4.1 Active management	1	1901	Risk Ratio (M‐H, Random, 95% CI)	0.39 [0.26, 0.58]
4.2 Expectant management	3	1234	Risk Ratio (M‐H, Random, 95% CI)	0.64 [0.42, 0.99]
5 Need for additional uterotonics; IM v. IV oxytocin	4	3135	Risk Ratio (M‐H, Random, 95% CI)	0.54 [0.36, 0.80]
5.1 IV oxytocin	1	1000	Risk Ratio (M‐H, Random, 95% CI)	0.57 [0.39, 0.82]
5.2 IM oxytocin	3	2135	Risk Ratio (M‐H, Random, 95% CI)	0.54 [0.24, 1.19]
6 Need for additional uterotonics; oxytocin dose < 10 IU v. 10 IU	4	3135	Risk Ratio (M‐H, Random, 95% CI)	0.54 [0.36, 0.80]
6.1 Oxytocin dose < 10 IU	2	234	Risk Ratio (M‐H, Random, 95% CI)	0.76 [0.22, 2.63]
6.2 Oxytocin dose 10 IU	2	2901	Risk Ratio (M‐H, Random, 95% CI)	0.48 [0.33, 0.68]