Comparison 4. Oxytocin versus ergot alkaloids‐‐subgroup analyses.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Blood loss 500 mL or more after delivery; active v. expectant management	8	2977	Risk Ratio (M‐H, Random, 95% CI)	0.90 [0.60, 1.35]
1.1 Active management	6	1743	Risk Ratio (M‐H, Random, 95% CI)	1.07 [0.47, 2.43]
1.2 Expectant management	2	1234	Risk Ratio (M‐H, Random, 95% CI)	0.82 [0.61, 1.10]
2 Blood loss 500 mL or more after delivery; IM v. IV oxytocin	10	3087	Risk Ratio (M‐H, Random, 95% CI)	0.84 [0.56, 1.25]
2.1 IM oxytocin	6	1278	Risk Ratio (M‐H, Random, 95% CI)	1.01 [0.48, 2.16]
2.2 IV oxytocin	4	1809	Risk Ratio (M‐H, Random, 95% CI)	0.77 [0.56, 1.05]
3 Blood loss 500 mL or more after delivery; oxytocin dose < 10 IU v. 10 IU	9	3077	Risk Ratio (M‐H, Random, 95% CI)	0.85 [0.56, 1.29]
3.1 Oxytocin dose < 10 IU	3	678	Risk Ratio (M‐H, Random, 95% CI)	0.66 [0.46, 0.95]
3.2 Oxytocin dose 10 IU	6	2399	Risk Ratio (M‐H, Random, 95% CI)	1.08 [0.54, 2.17]
4 Need for additional uterotonics; active v. expectant management	7	2078	Risk Ratio (M‐H, Random, 95% CI)	1.01 [0.48, 2.09]
4.1 Active management	6	1893	Risk Ratio (M‐H, Random, 95% CI)	0.96 [0.40, 2.32]
4.2 Expectant management	1	185	Risk Ratio (M‐H, Random, 95% CI)	1.25 [0.57, 2.72]
5 Need for additional uterotonics; IM v. IV oxytocin	8	2178	Risk Ratio (M‐H, Random, 95% CI)	0.87 [0.41, 1.82]
5.1 IM oxytocin	6	1428	Risk Ratio (M‐H, Random, 95% CI)	1.16 [0.47, 2.83]
5.2 IV oxytocin	2	750	Risk Ratio (M‐H, Random, 95% CI)	0.41 [0.13, 1.26]
6 Need for additional uterotonics; oxytocin dose < 10 IU v. 10 IU	8	2180	Risk Ratio (M‐H, Random, 95% CI)	0.87 [0.41, 1.83]
6.1 Oxytocin dose < 10 IU	3	678	Risk Ratio (M‐H, Random, 95% CI)	0.52 [0.18, 1.45]
6.2 Oxytocin dose 10 IU	5	1502	Risk Ratio (M‐H, Random, 95% CI)	1.22 [0.42, 3.48]